The administration of SCFAs mix significantly reduced the tumor incidence and size in mice with AOM/DSS-induced colitis associated colorectal cancer. The effects of SCFAs mix on colonic epithelial cellular proliferation were also assessed using Ki67 immunohistochemistry and TUNEL staining. Macroscopic and histological studies were performed to examine the colorectal inflammation and tumorigenesis in AOM/DSS-induced mice treated with or without SCFA mix. SCFAs mix (67.5 mM acetate, 40 mM butyrate, 25.9 mM propionate) was administered in drink water during the study period. Model of colitis-associated colorectal cancer in male BALB/c mice was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). The chemopreventive effect of SCFAs in colitis-associated colorectal cancer was evaluated in this study. Whether SCFAs suppress tumorigenesis in colitis-associated colorectal cancer remains unknown. Reduced short-chain fatty acids (SCFAs) have been reported in patients with ulcerative colitis, and increased intake of dietary fiber has shown to be clinically beneficial for colitis. Tian, Yun Xu, Qing Sun, Liqun Ye, Ying Ji, Guozhong Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development. CPU usage can be tracked by individual cores or with.
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